Synthesis of enantiomerically pure 9-[(1'R,2'R,3'S)-bis(hydroxymethyl)thietan-1'-yl]adenine, 3'-thio analog of oxetanocin A

Article abstract of DOI:10.1016/S0040-4039(99)01515-4

The enantiomerically pure synthesis of 9-[(1'R,2'R,3'S)-bis(hydroxymethyl)thietan-1'-yl]adenine 2, 3'-thio analog of oxetanocin A, was achieved via coupling with sulfoxide 17 and 6-chloropurine in the presence of TMSOTf and Et₃N under the Pummerer reaction conditions.