Tetrahedron p. 9898 - 9905 (2013)
Update date:2022-08-04
Topics:
Li, Pei-Ze
Liu, Zai-Qun
Eight ferrocenyl and three corresponding phenyl dendritic-like antioxidants with dihydropyrazole or pyrazole as the core were synthesized and their antioxidant abilities to scavenge 2,2′-azinobis(3-ethylbenzothiazoline-6- sulfonate) cationic radical (ABTS+) and to protect DNA against 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH)-induced oxidation were evaluated. It was found that the antioxidant abilities of almost all of the ferrocenyl dendritic-like antioxidants are greater than those of the corresponding phenyl dendritic-like antioxidants remarkably. Moreover, the structure-activity relationships of all these dendritic-like antioxidants were investigated in detail. The quantitative contributions of ferrocenyl group, hydroxyl group, and dihydro-structure in the heterocyclic core to the values of n, napp and n+napp in scavenging ABTS+ and the values of n in protecting DNA against AAPH-induced oxidation were also calculated.
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Doi:10.1080/10426509908546204
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