Condensed-purines syntheses of tetrahydro-1,4-diazepino[1,2,3-gh]purin- 2-one and hexahydro-1,4-diazocino[1,2,3-gh]purin-2-one

DOI: 10.1248/cpb.47.1322

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1322 - 1325 (1999)

Update date:2022-07-30

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Authors:

Suzuki, Hirokazu

Sawanishi, Hiroyuki

Yamamoto, Kenji

Miyamoto, Ken-Ichi

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Article abstract of DOI:10.1248/cpb.47.1322

1,4-Pyrimido- (2a), 1,4-diazepino- (2b), and 1,4-diazocino[1,2,3- gh]purine (2c) were designed as selective cAMP-phosphodiesterase 4 (PDE 4) inhibitors. The desired condensed-purines (2b,c) were synthesized by reaction of 7-aminoalkyl-3-propylpurine-2,4-d

Full text of DOI:10.1248/cpb.47.1322

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