Condensed-purines syntheses of tetrahydro-1,4-diazepino[1,2,3-gh]purin- 2-one and hexahydro-1,4-diazocino[1,2,3-gh]purin-2-one

DOI: 10.1248/cpb.47.1322

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1322 - 1325 (1999)

Update date:2022-07-30

Topics:

Authors:

Suzuki, Hirokazu

Sawanishi, Hiroyuki

Yamamoto, Kenji

Miyamoto, Ken-Ichi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.47.1322

1,4-Pyrimido- (2a), 1,4-diazepino- (2b), and 1,4-diazocino[1,2,3- gh]purine (2c) were designed as selective cAMP-phosphodiesterase 4 (PDE 4) inhibitors. The desired condensed-purines (2b,c) were synthesized by reaction of 7-aminoalkyl-3-propylpurine-2,4-d

Full text of DOI:10.1248/cpb.47.1322

NII-Electronic Library Service

Products guided by the article

Product name:Carbamic acid, [4-(1,2,3,6-tetrahydro-2,6-dioxo-3-propyl-7H-purin-7-yl)butyl]-, phenylmethyl ester

Cas No:251918-43-1

R&D Labs maybe for 251918-43-1

Synchemie Co., Ltd.

website:http://www.synchemie.com/

Contact:+86-574-87642758

Address:Room 901, Yinyi Bund Building， 132 Renmin Road
Amadis Chemical Co., Ltd.

website:http://www.amadischem.com

Contact:86-571-89925085

Address:Watts Cosine.No.166.Xiangmao Road.
Xiamen Goodhealth Pharmchem Co., Ltd.

Contact:0086-592-2097683

Address:404R No.2 54# Minzu Rd., Xiamen, China
Hotechem Shanghai Co., Ltd

Contact:13120882795；+86-21-34621078;+86-021-31122318

Address:Suite 2,No.2715 Longwu Road
Xi'an Unique Electronic and Chemical Co., Ltd.

Contact:+86-029-88238008

Address:1703# B BUILDING WEST ELECTRONIC ZONE, XI'AN, CHINA

Relevant to this article

Synthesis and characterization of salts containing the BrO ₃F₂^- anion; a rare example of a bromine(VII) species

Doi:10.1021/ja0402607
(2005)
Reactions of New Osmium-Dihydride Complexes with Terminal Alkynes: Metallacyclopropene versus Metal-Carbyne. Influence of the Alkyne Substituent

Doi:10.1021/om990426q
(1999)
Self-assembly of amphoteric azopyridine carboxylic acids: Organized structures and macroscopic organized morphology influenced by heat, pH change, and light

Doi:10.1021/ja001790f
(2000)
Enantioselective Synthesis of Axially Chiral Biaryls by Diels-Alder/Retro-Diels-Alder Reaction of 2-Pyrones with Alkynes

Doi:10.1021/jacs.1c04759
(2021)
Synthesis and Atropo-diastereoselective Ring Cleavage of a [Cp*Ru]-Complexed Biaryl Lactone: Experimental and Computational Investigations

Doi:10.1021/om9906520
(1999)
A Convenient One-Pot Procedure to Arylcyclobutenes from Arylacetylenes

Doi:10.1021/jo990596c
(1999)

Article Doi