Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assays.

Article abstract of DOI:10.1016/S0960-894X(99)00398-4

Evaluation of a biased "library" of pyrrolo[2,3-d]pyrimidines using yeast-based functional assays expressing human A1- and A2a-adenosine receptors, led to the A1 selective antagonist 4b. A direct correlation between yeast functional activity and binding d