Stereospecific synthesis of a GS 4104 metabolite: Determination of absolute stereochemistry and influenza neuraminidase inhibitory activity

DOI: 10.1016/S0960-894X(99)00479-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2811 - 2814 (1999)

Update date:2022-08-05

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Authors:

Lew, Willard

Escarpe, Paul A.

Mendel, Dirk B.

Sweeny, David J.

Kim, Choung U.

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Article abstract of DOI:10.1016/S0960-894X(99)00479-5

The total synthesis for the determination of the absolute stereochemistry of a GS 4104 metabolite 3 is described. In addition, the influenza neuraminidase inhibitory activity of 3 and related intermediates are reported.

Full text of DOI:10.1016/S0960-894X(99)00479-5

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