Design and synthesis of isoxazole containing bioisosteres of epibatidine as potent nicotinic acetylcholine receptor agonists

DOI: 10.1248/cpb.47.1501

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1501 - 1505 (1999)

Update date:2022-08-03

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Authors:

Singh, Satendra

Avor, Kwasi S.

Pouw, Buddy

Seale, Thomas W.

Basmadjian, Garo P.

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Article abstract of DOI:10.1248/cpb.47.1501

An efficient synthesis of isoxazole containing isosteres of epibatidine is described. The synthesis proceeded from N-tert-butoxycarbonyl (Boc)-exo-2- (methoxycarbonyl)-7-azabicyclo[2.2.1]heptane (9). Compound 9 was reacted with the dilithium salt of an ap

Full text of DOI:10.1248/cpb.47.1501

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Product name:7-Azabicyclo[2.2.1]heptane,2-(5-isoxazolyl)-,(1R,2S,4S)-rel-(9CI)

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