Design and synthesis of isoxazole containing bioisosteres of epibatidine as potent nicotinic acetylcholine receptor agonists

DOI: 10.1248/cpb.47.1501

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1501 - 1505 (1999)

Update date:2022-08-03

Topics:

Authors:

Singh, Satendra

Avor, Kwasi S.

Pouw, Buddy

Seale, Thomas W.

Basmadjian, Garo P.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.47.1501

An efficient synthesis of isoxazole containing isosteres of epibatidine is described. The synthesis proceeded from N-tert-butoxycarbonyl (Boc)-exo-2- (methoxycarbonyl)-7-azabicyclo[2.2.1]heptane (9). Compound 9 was reacted with the dilithium salt of an ap

Full text of DOI:10.1248/cpb.47.1501

NII-Electronic Library Service

Products guided by the article

Product name:7-Azabicyclo[2.2.1]heptane,2-(5-isoxazolyl)-,(1R,2S,4S)-rel-(9CI)

Cas No:252305-03-6

R&D Labs maybe for 252305-03-6

JiYi Chemical (Beijing) Co., Ltd.

Contact:+86-10-89385733

Address:Shilou Town of Fangshan District， Beijing
Pale Palm Imex

Contact:+36(21)2523420

Address:Head office: 1102 Budapest, SZENT LASZLO TER 24/B. 1/1., HUNGARY / CHINA
jiangsu hualin chemical co.,ltd.

Contact:86-25-87787402

Address:jaingsu,china
Anhui New Star Pharmaceutical Development Co., Ltd

Contact:013956922763

Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
Shanghai Surseechem Co.,Ltd.

Contact:+86-21-61318535

Address:Building 29,No.2139 Xizha Road, Fengxian District, Shanghai

Relevant to this article

Synthesis of novel 4-(5'-pyrrolidinyl)-β-lactams

Doi:10.1016/S0040-4020(99)00867-4
(1999)
The assembly of β-methylene-TAD, a metabolically stable analogue of the antitumor agent TAD, by the stepwise esterification of monodeprotected methylenebis-(phosphonate) benzyl esters under Mitsunobu conditions

Doi:10.1016/S0960-894X(99)00544-2
(1999)
Porphodimethene-zirconium: A new entry into zirconium macrocycle organometallic chemistry

Doi:10.1021/om990688s
(1999)
A novel route to pyrrolo[2,1-c][1,4]benzodiazepin-5-ones. Formal total synthesis of (±)-DC-81

Doi:10.1021/ol991100g
(1999)
Platinum-catalyzed acrylonitrile hydrophosphination. P-C bond formation via olefin insertion into a Pt-P bond

Doi:10.1021/om990745h
(1999)
Thermolysis of 2-(3-phenylsulfonyiprop-l-ynyl)benzonitrile: An aza-Myers type cyclization to isoquinolines

Doi:10.1039/a905509f
(1999)

Article Doi