Design and synthesis of isoxazole containing bioisosteres of epibatidine as potent nicotinic acetylcholine receptor agonists

DOI: 10.1248/cpb.47.1501

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1501 - 1505 (1999)

Update date:2022-08-03

Topics:

Authors:

Singh, Satendra

Avor, Kwasi S.

Pouw, Buddy

Seale, Thomas W.

Basmadjian, Garo P.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.47.1501

An efficient synthesis of isoxazole containing isosteres of epibatidine is described. The synthesis proceeded from N-tert-butoxycarbonyl (Boc)-exo-2- (methoxycarbonyl)-7-azabicyclo[2.2.1]heptane (9). Compound 9 was reacted with the dilithium salt of an ap

Full text of DOI:10.1248/cpb.47.1501

NII-Electronic Library Service

Products guided by the article

Product name:7-Azabicyclo[2.2.1]heptane,2-(5-isoxazolyl)-,(1R,2S,4S)-rel-(9CI)

Cas No:252305-03-6

R&D Labs maybe for 252305-03-6

Sarchem Laboratories, Inc.

Contact:732.938.2777

Address:5012 Industrial Road Farmingdale, NJ 07727
HUNAN OUYA BIOLOGICAL CO.,LTD

Contact:+8613400661290

Address:No 908,Kangwan Rd, Liuyang Economic
Shanghai better-in Medical Technology Co.,LTD.

Contact:+86-21-38921049

Address:Lane 720 zhangjianggaoke cailun road, Pudong, Shanghai, room 513
ALPHA PHARMACEUTICAL CO，LTD JIANGSU

Contact:+86-527-84829968,+86-527-84829998

Address:suqian city
Allright GC (Jinan) Biotechnology Ltd.

website:https://www.argcbiotech.com/

Contact:86-18405413579-

Address: No.27566 of Jingshiroad, Huaiyin District, Jinan City(250011), Shandong Province, China.

Relevant to this article

Synthesis of novel 4-(5'-pyrrolidinyl)-β-lactams

Doi:10.1016/S0040-4020(99)00867-4
(1999)
The assembly of β-methylene-TAD, a metabolically stable analogue of the antitumor agent TAD, by the stepwise esterification of monodeprotected methylenebis-(phosphonate) benzyl esters under Mitsunobu conditions

Doi:10.1016/S0960-894X(99)00544-2
(1999)
Porphodimethene-zirconium: A new entry into zirconium macrocycle organometallic chemistry

Doi:10.1021/om990688s
(1999)
A novel route to pyrrolo[2,1-c][1,4]benzodiazepin-5-ones. Formal total synthesis of (±)-DC-81

Doi:10.1021/ol991100g
(1999)
Platinum-catalyzed acrylonitrile hydrophosphination. P-C bond formation via olefin insertion into a Pt-P bond

Doi:10.1021/om990745h
(1999)
Thermolysis of 2-(3-phenylsulfonyiprop-l-ynyl)benzonitrile: An aza-Myers type cyclization to isoquinolines

Doi:10.1039/a905509f
(1999)

Article Doi