Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: Novel biaryl indazoles as P2/P2' substituents

DOI: 10.1016/S0960-894X(99)00564-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3217 - 3220 (1999)

Update date:2022-08-04

Topics:

Authors:

Patel, Mona

Rodgers, James D.

McHugh Jr., Robert J.

Johnson, Barry L.

Cordova, Beverly C.

Klabe, Ronald M.

Bacheler, Lee T.

Erickson-Viitanen, Susan

Soo S, Ko

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00564-8

The preparation of unsymmetrical cyclic ureas bearing novel biaryl indazoles as P2/P2' substituents was undertaken, utilizing a Suzuki coupling reaction as the key step. Compound 6i was equipotent to the lead compound of the series SE063.

Full text of DOI:10.1016/S0960-894X(99)00564-8

Products guided by the article

Product name:5-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-2-fluoro-benzoic acid methyl ester

Cas No:256345-52-5

R&D Labs maybe for 256345-52-5

Kunshan Yalong Trading Co,.Ltd

Contact:86-512-57621185

Address:805-807 Room Hongqiao Mansion ,1088 West Qianjin Road, Kunshan, Jiangsu，China
taizhou creating bio-pharm co.,ltd.

Contact:+86- 576- 88827176

Address:715 room ,unit A.junyue Building,Jiaojiang,Taizhou,Zhejiang,China
Nanjing Norris Pharm Technology Co., Ltd.

Contact:+86-13901585132

Address:2 Qiande Road, Jiangning sciencepark Hi-Tech Zone, Nanjing, P.R.China
ANHUI WEICHI CHEMICAL CO.,LTD

website:http://www.weichichem.com

Contact:+8613912949432

Address:Fine Chemical Industrial Base,Wujiang town,He County,Anhui China.
SuZhou LaiTeou

Contact:+86-0512-88957371

Address:shanghai

Relevant to this article

C-C coupling of activated alkanes with carbon dioxide by <(phen)(Ph3P)Cu(O2COH)>

Doi:10.1016/0022-328X(88)80403-0
(1988)
An isoxazole strategy for the synthesis of alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylates - versatile building blocks for assembling pyrrolo-fused heterocycles

Doi:10.1039/d1ob00053e
(2021)
Intermolecular Amidation of Quinoline N-Oxides with Arylsulfonamides under Metal-Free Conditions

Doi:10.1021/acs.orglett.7b02922
(2017)
A highly efficient and practical new PEG-bound bi-cinchona alkaloid ligand for the catalytic asymmetric aminohydroxylation of alkenes

Doi:10.1016/j.tetasy.2004.05.007
(2004)
Doi:10.1021/jm00297a048
(1970)
Doi:10.1016/S0040-4020(01)97848-2
(1970)

Article Doi