Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: Novel biaryl indazoles as P2/P2' substituents

DOI: 10.1016/S0960-894X(99)00564-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3217 - 3220 (1999)

Update date:2022-08-04

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Authors:

Patel, Mona

Rodgers, James D.

McHugh Jr., Robert J.

Johnson, Barry L.

Cordova, Beverly C.

Klabe, Ronald M.

Bacheler, Lee T.

Erickson-Viitanen, Susan

Soo S, Ko

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Article abstract of DOI:10.1016/S0960-894X(99)00564-8

The preparation of unsymmetrical cyclic ureas bearing novel biaryl indazoles as P2/P2' substituents was undertaken, utilizing a Suzuki coupling reaction as the key step. Compound 6i was equipotent to the lead compound of the series SE063.

Full text of DOI:10.1016/S0960-894X(99)00564-8

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