An efficient synthesis of a 4'-phosphonodifluoromethyl-3'-formyl-phenylalanine containing Src SH2 ligand

DOI: 10.1016/S0960-894X(99)00545-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3109 - 3112 (1999)

Update date:2022-07-30

Topics: Ligand Chemical Synthesis Efficient Synthesis Experimental Design Phenylalanine

Authors:

Shakespeare, William C.

Bohacek, Regine S.

Narula, Surinder S.

Azimioara, Mihai D.

Yuan, Ruth W.

Dalgarno, David C.

Madden, Laura

Botfield, Martyn C.

Holt, Dennis A.

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Article abstract of DOI:10.1016/S0960-894X(99)00545-4

A CuBr-mediated, regioselective cross-coupling between methyl 2,5-diiodobenzoate (4) and [(diethoxyphosphinyl)difluoromethyl]zinc bromide is reported. Palladium-catalyzed incorporation of an amino acid side chain, followed by subsequent modifications resu

Full text of DOI:10.1016/S0960-894X(99)00545-4

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