Synthesis and biological activity of a novel series of indole-derived PPARγ agonists

DOI: 10.1016/S0960-894X(99)00603-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3329 - 3334 (1999)

Update date:2022-07-30

Topics:

Authors:

Henke, Brad R.

Adkison, Kimberley K.

Blanchard, Steven G.

Leesnitzer, Lisa M.

Mook Jr., Robert A.

Plunket, Kelli D.

Ray, John A.

Roberson, Claudia

Unwalla, Rayomand

Willson, Timothy M.

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Article abstract of DOI:10.1016/S0960-894X(99)00603-4

The synthesis and structure-activity relationships of a novel series of indole 5-carboxylic acids that bind and activate peroxisome proliferator- activated receptor gamma (PPARγ) are reported. These new analogs are selective for PPARγ vs the other PPAR su

Full text of DOI:10.1016/S0960-894X(99)00603-4

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Product name:{3-[2-(4-methoxy-phenyl)-ethyl]-2-phenyl-1H-indol-5-yl}-acetic acid ethyl ester

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