Tetrahedron Letters p. 8989 - 8992 (1999)
Update date:2022-07-29
Topics:
Khan, Noshena
Bastola, Shyamal R.
Witter, Kevin G.
Scheiner, Peter
L-homolamivudine (2a, (2R,5R)-(+)-cis-5-(1-cytosinylmethyl)-2-hydroxymethyl-1,3-oxathiolane) and its 5-fluoro congener (2b, L-homoFTC) have been prepared from (R)-glycidol by diastereoselective synthesis. Enantioselectivity resulted from stereoselective cyclothioacetalization that preferentially gave the (2R,5R)-cis-2,5-disubstituted-1,3-oxathiolane (5), cis/trans = 5.7.
View MoreDalian RSD International Trade Co.,Ltd.(expird)
Contact:86-22-60875058 58610575
Address:Wantong International Areas, Hongqiao District, Tianjin, China.China
Shanghai Yuanye Bio-Technology Co., Ltd.
website:http://www.shyuanye.com
Contact:+86-21-61845781
Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China
Guangxi Shanyun Biochemical Science and Technology Co., Ltd
Contact:+86-0772--6828887
Address:#2 Industrial Park of Luzhai County, Liuzhou, Guangxi, China
Zhejiang Rongkai Chemical Technology Co.,Ltd.
Contact:+86-578-8185786
Address:Shangjiang Industrial Zone,Suichang
Lanzhou huibang biological chemical technology Co., LTD
Contact:0931-7843964
Address:NO.2011,Yannan Road,Chengguan,
Doi:10.1021/bi00840a072
(1969)Doi:10.1107/S0108270199014249
(2000)Doi:10.1039/c39860001159
(1986)Doi:10.1021/jo01169a008
(1947)Doi:10.1007/BF00477423
()Doi:10.1016/0040-4020(58)88039-4
(1958)
