European Journal of Medicinal Chemistry p. 843 - 850 (2001)
Update date:2022-08-05
Topics: Synthesis Derivatives Solubility Cytotoxicity Minimum inhibitory concentration (MIC) Purification In vitro Testing Structure-Activity Relationship (SAR) Spectroscopic Characterization Dose-Response Curve Cell viability assay
De Souza, Ana O
Santos Junior, Rubens R
Ferreira-Julio, Joao F
Rodriguez, Jaime A
Melo, Patricia S
Haun, Marcela
Sato, Daisy N
Duran, Nelson
The derivatives of 3-(4′-bromo-[1,1′-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2- propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains of Mycobacterium sp. (ATCC) and M. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction to measure the cellular viability.
View MoreHangzhou Haiqiang Chemical Co.,Ltd.
Contact:+86-571-86960370
Address:Add: 5/F, Around Town North Road,No. 10, Hangzhou, Zhejiang,China
SHAANXI TOP PHARM CHEMICAL CO.LTD
Contact:+86-029-85733403
Address:No.108 ,west sector,south er huan,xi'an,china
XI'AN CHUKANG BIOTECHNOLOGY CO.,LTD
Contact:29-63685658 63685359
Address:Room 3-1202,Building 1,Oriental oasis,East of Xianning Road,Xi'an,Shaanxi 710043 P.R.China
Shanghai Pinewood Fine Chemical Co., Ltd.
website:http://www.pinewoodchem.com
Contact:0086-21-62417129,62414096
Address:Suite B, 27F, No.2, Lane 600, Tianshan Road, Shanghai
Changsha Yihai Chemical Technology Co.,ltd
website:http://www.cs-yihai.com/
Contact:0731- 85620465
Address:Room 23005, unit 2, the northern building of Xiangsong international building , NO.259 Shaoshan Road , Changsha , Hunan, China.(mainland)
Doi:10.1021/ja01053a033
(1969)Doi:10.1016/S0960-894X(97)10083-X
(1998)Doi:10.1021/om990872d
(2000)Doi:10.1021/bi00839a049
(1969)Doi:10.1021/jo991181u
(2000)Doi:10.1007/s11176-005-0019-2
(2004)