European Journal of Medicinal Chemistry p. 843 - 850 (2001)
Update date:2022-08-05
Topics: Synthesis Derivatives Solubility Cytotoxicity Minimum inhibitory concentration (MIC) Purification In vitro Testing Structure-Activity Relationship (SAR) Spectroscopic Characterization Dose-Response Curve Cell viability assay
De Souza, Ana O
Santos Junior, Rubens R
Ferreira-Julio, Joao F
Rodriguez, Jaime A
Melo, Patricia S
Haun, Marcela
Sato, Daisy N
Duran, Nelson
The derivatives of 3-(4′-bromo-[1,1′-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2- propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains of Mycobacterium sp. (ATCC) and M. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction to measure the cellular viability.
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