Chemical and Pharmaceutical Bulletin p. 272 - 277 (2000)
Update date:2022-08-02
Topics:
Nozawa, Masako
Takahashi, Keiko
Kato, Keisuke
Akita, Hiroyuki
Syntheses of (S)-chroman-2-carboxaldehyde congener 1 and (S)-chiral isoprene unit 3 were achieved based on the enzymatic acetylation of (±)- chroman-2-methanol 6 and (±)-(2,3)-anti-2-methyl-3-(p-methoxyphenyl)-1,3- propane diol 12, respectively. Synthesis of the side-chain part corresponding to (3R,7R)-3,7,11-trimethyldodecan-1-ol 27 was achieved by the coupling reaction of (S)-3 and (R)-3,7-dimethyloctyl iodide 4. The Wittig reaction of (3R,7R)-phosphonium salt 2 derived from (3R,7R)-27 and (S)-1 gave the olefin 28 which was subjected to catalytic hydrogenation to afford (2R,4'R,8'R)-α- tocopherol.
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(2007)Doi:10.1039/c9sc05252f
(2020)Doi:10.1016/0039-128X(74)90037-3
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(2000)Doi:10.1021/ja992099j
(2000)
