Chemical and Pharmaceutical Bulletin p. 235 - 237 (2000)
Update date:2022-07-31
Topics:
Nakamura, Takashi
Nishi, Hiroyuki
Kokusenya, Yoshio
Hirota, Kenichi
Miura, Yozo
In order to clarify the mechanism of action for the antioxidative activity of fluvastatin sodium (FLV, (±)-sodium (3RS, 5RS, 6E)-7-[3-(4- fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptanoate) and its derivatives, reaction of the corresponding methyl ester of FLV with di-tert-butyl diperoxyoxalate was examined, and the corresponding keto derivative was isolated from the reaction mixture. On the basis of this result, it was concluded that the active site is the allylic carbon conjugated with the indole ring.
View MoreTianjin Crest Pharmaceutical R&D Co., Ltd. （Tianjin Yao Technology Development Co., Ltd.）(expird)
Contact:+86-22-66211386
Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
website:http://www.cheminn.com/
Contact:86-531-67875205
Address:No.9-2,South of Shanda Road, Jinan ,China
UK SHAREPOINT INTERNATIONAL TRADE CO., LTD(expird)
Contact:44-20-31299469
Address:FLAT 107 25 INDESCON SQUARE LONDON UNITED KINGDOM E14 9DG
Hefei Lifeon Pharmaceutical Co., Ltd.
Contact:+86-551-65328450
Address:No522 Wangjiang West Road
Contact:+86-571-86217390
Address:No.567 Dengcai Street,Sandun,Westlake District,Hangzhou310030,Zhejiang,China.
Doi:10.1246/bcsj.45.1867
(1972)Doi:10.1039/C39720000521
(1972)Doi:10.1016/S0960-894X(96)00551-3
(1996)Doi:10.1007/BF02547480
(1995)Doi:10.1016/S0022-328X(01)01094-4
(2001)Doi:10.1021/ic010625d
(2001)
