Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists

DOI: 10.1016/S0960-894X(96)00551-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2999 - 3002 (1996)

Update date:2022-07-31

Topics:

Authors:

Cheng Cheng

Lee Lee

Klutchko

Winters Winters

Reynolds

Welch Welch

Flynn Flynn

Doherty Doherty

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Article abstract of DOI:10.1016/S0960-894X(96)00551-3

Screening of a compound library against endothelin receptors (ET(A) and ET(B)) revealed PD 102566 (compound 1) as an ET(A) selective antagonist. Synthesis and structure-activity relationships (SAR) of a series of analogs are described.

Full text of DOI:10.1016/S0960-894X(96)00551-3

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Product name:1-Cyclohexene-1-carboxylic acid, 2-(phenylamino)-, ethyl ester

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