Potassium Permanganate-Mediated Radical Reactions: Chemoselective Addition of Acetone to Olefins

Article abstract of DOI:10.1016/0040-4020(95)00563-N

A practical and efficient protocol for the radical addition of acetone (1) to olefins 2a-d, mediated by potassium permanganate, has been developed.The in situ generation of manganese(III) allows the chemoselective synthesis of saturated C-C bond formation products 4a-d in 39-58percent yield.Furthermore, the required amount of manganese is reduced drastically in account of the catalytic reaction cycle.