Design, synthesis and biological evaluation of pyridine-phenylpiperazines: A novel series of potent and selective α(1a)-adrenergic receptor antagonist

Article abstract of DOI:10.1016/S0968-0896(00)00151-6

Beginning from the screening hit and literature α₁-adrenergic compounds, a hybridized basic skeleton A was proposed as the pharmacophore for potent and selective α(1a)-AR antagonists. Introduction of a hydroxy group to increase the flexibility