Bioorganic and Medicinal Chemistry Letters p. 641 - 646 (1999)
Update date:2022-08-05
Topics:
De Laszlo, Stephen E.
Hacker, Candice
Li, Bing
Kim, Dooseop
MacCoss, Malcolm
Mantlo, Nathan
Pivnichny, James V.
Colwell, Larry
Koch, Gregory E.
Cascieri, Margaret A.
Hagmann, William K.
The SAR of 2-pyridyl-3,5-diaryl pyrroles, ligands of the human glucagon receptor and inhibitors of p38 kinase, were investigated. This effort resulted in the identification of 2-(4-pyridyl)-5-(4-chlorophenyl)-3-(5- bromo-2-propyloxyphenyl)pyrrole 49 (L-168,049), a potent (Kb = 25 nM), selective antagonist of glucagon.
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(2000)
