Bioorganic and Medicinal Chemistry Letters p. 641 - 646 (1999)
Update date:2022-08-05
Topics:
De Laszlo, Stephen E.
Hacker, Candice
Li, Bing
Kim, Dooseop
MacCoss, Malcolm
Mantlo, Nathan
Pivnichny, James V.
Colwell, Larry
Koch, Gregory E.
Cascieri, Margaret A.
Hagmann, William K.
The SAR of 2-pyridyl-3,5-diaryl pyrroles, ligands of the human glucagon receptor and inhibitors of p38 kinase, were investigated. This effort resulted in the identification of 2-(4-pyridyl)-5-(4-chlorophenyl)-3-(5- bromo-2-propyloxyphenyl)pyrrole 49 (L-168,049), a potent (Kb = 25 nM), selective antagonist of glucagon.
View MoreLuojiang Chenming Biological Products Co
Contact:+86 15000297032
Address:GROUP NO.4, HE SHENG VILLAGE, PANLONG TOWN,
Contact:0086-27-83607103/83642615
Address:No.498, Jianshe Ave, Wuhan, China
Jewim Pharmaceutical (Shandong) Co., Ltd
Contact:+8615621883869
Address:山东省泰安市高新技术产业开发区配天门大街西首
Qingdao XinYongAn Chemicals Co., Ltd
Contact:+86-532-81107967
Address:Chengyang dual-port industrial park by the sea，Qingdao
Chemieliva Pharmaceutical Co., Ltd.
website:http://www.chemieliva.com
Contact:+86-23-67770219
Address:99 Longhua Road, Yubei District, 401147, Chongqing, China Email: sales@chemieliva.com Tel:0086-23-67770219 Fax: 0086-23-67770220 Attn: Andy Huang
Doi:10.1021/jo01017a034
(1965)Doi:10.1016/S0040-4039(00)72677-3
(1975)Doi:10.1021/jo00416a042
(1978)Doi:10.1021/jo00811a001
(1971)Doi:10.1016/S0968-0896(00)00058-4
(2000)Doi:10.1039/b002312o
(2000)
