´
´
V. Marchan, C. Rodrıguez-Tanty, M. Estrada, E. Pedroso, A. Grandas
FULL PAPER
done, Nu ϭ nucleoside, Phac ϭ phenylacetyl, PS ϭ polysty-
rene-co-1%-divinylbenzene resin functionalized as p-methyl-
benzhydrylamine, PyBOP ϭ benzotriazole-1-yl-oxy-tris(pyrrol-
idino)phosphonium hexafluorophosphate, R ϭ resin (solid
matrix), TBAF ϭ tetrabutylammonium fluoride, TCA ϭ tri-
chloroacetic acid, Tfa ϭ trifluoroacetyl, TFA ϭ trifluoroacetic
acid, TMG ϭ tetramethylguanidine.
Acknowledgments
This work was supported by funds from the Spanish MEC (grant
PB97Ϫ0941-C02Ϫ01) and the Generalitat de Catalunya
(SGR98Ϫ0001 and Centre de Referencia de Biotecnologia). The
authors thank Dr. Irene Fernandez and Dr. Marta Vilaseca of the
Servei d’Espectrometria de Masses and acknowledge the use of the
facilities of the Servei de RMN d’Alt Camp (Serveis Cientıfico-
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Abbreviations: Aa ϭ amino acid, Boc ϭ tert-butyloxycarbonyl,
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hexafluorophosphate, HBTU
ϭ 2-(1H-benzotriazole-1-yl)-
1,1,3,3-tetramethyluronium hexafluorophosphate, HMFS ϭ
2-(9-oxymethylfluorenyl)succinyl, HOBt ϭ 1-hydroxybenzotri-
´
azole, Hse
ϭ
homoserine, iBu
ϭ
isobutyryl, MMT
ϭ
M. Gairı, P. Lloyd-Williams, F. Albericio, E. Giralt, Tetrahe-
4-methoxytrityl, MPLC ϭ medium-pressure liquid chromato-
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Received January 24, 2000
[O00043]
2500
Eur. J. Org. Chem. 2000, 2495Ϫ2500