A Convenient Synthesis of (E)-γ-Hydroxy- and (E)-γ-Keto-α,β-Unsaturated Sulfoxides

Article abstract of DOI:10.1016/00404-0399(50)0878G-

(E)-γ-Hydroxy and (E)-γ-keto-α,β-unsaturated sulfoxides have been easily prepared in good chemical yield from simple aldehydes 2 and chiral bis-sulfoxide 4 using a SPAC-type reaction.The one-pot procedure is based on a Knoevenagel condensation, subsequent