Bioorganic and Medicinal Chemistry Letters p. 1823 - 1826 (2000)
Update date:2022-07-31
Topics:
Murakami, Nobutoshi
Wang, Weiqi
Tamura, Satoru
Kobayashi, Motomasa
The carba analogue, in which a methylene group is substituted for the oxygen atom linked to C-15, and 20-deoxo analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, were synthesized. Both analogues lacking the 15,20-ester function, which was easily metabolized in serum, showed good stability in serum as well as moderate cytotoxic activity against KB cells and better solubility. (C) 2000 Elsevier Science Ltd. All rights reserved.
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