Bioorganic and Medicinal Chemistry Letters p. 1299 - 1302 (2000)
Update date:2022-07-30
Topics:
Matulic-Adamic, Jasenka
Daniher, Andrew T.
Karpeisky, Alexander
Haeberli, Peter
Sweedler, David
Beigelman, Leonid
A series of novel 2'-modified nucleoside 5'-triphosphates was synthesized. The amino, imidazole, and carboxylate functionalities were attached to the 5-position of pyrimidine base of these molecules through alkynyl and alkyl spacers, respectively. Two different phosphorylation methods were used to optimize the yields of these highly modified triphosphates. (C) 2000 Elsevier Science Ltd. All rights reserved.
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