466
Table II.
Measures of
was
on
and
15,
(Tr-
group),
for all MI
to whether
30 ofinfarction
and
QTcD
given
1, 3, 5,
10,
or not
according
days
patients
arrhythmia
group.
(Tr+
group)
thrombolytic therapy
major
vs
(+)
0.001.
vs
(-):
(+),
(-),
*Thrombolytic
thrombolytic
p <
tmajor arrhythmia
Thrombolytic
after
thrombolytic
and total:
0.001.
p <
<
after MI
the
other
On
QTD
the time
risk
after 1
However,
0.05).
ofmeasurementof
uation after AMI. Toour
hand,
(p
ligation.
promptly
coronary
is not
for
eval-
only
action
and
durations
measurements
clear
day,
riod
potential
pe-
refractory
there is
are
knowledge,
abnormally
pro-
reported
one
that
has
been
this
Such
study
investigates
investigated
subject: Glancy
longed.15,16
prolongation
and associates 12
interval
the time
of
6
in
excised at
the time of
course
and
of AMI as
human
myocardium
In
a
newreport,
Schneider and
QT
1, 2, 3,
changes during days
transplantation. 17
after MI.
found
and
on
1
his co-workers18 observed that
ocardial infarction is determined
after
QTcD
QTD
They
day
my-
162.3 63.8
141.8 44ms,
the extent of
107 44.8
ms,
by
ms on
and
6
of
scarred tissue. It has been knownthat
the
117.4
67.4
These results are consistent
our observations in
ms,
MI,
with
2, 3,
days
major-
tissue
of
scar
formation occurs dur-
respectively.
ity
ing
myocardial
there are
first 2 weeks after MI. 19
ofelec-
However,
general.
Heterogeneity
data:
and co-workers
associated with
the
conflicting
Glancy
suggest-
trophysiological changes
dy-
ed that at
hadreturned
consists of
namicevents ofischemic and
QTcD
hospital discharge,
subsequent healing,
of fibrous and viable
tissue,
to
beginning levels. Their study group
intermingling
with
after
be the result of
of
has
crease
as an
in-
for the
20
The
andhave no data
6
been
only
patients,
day
suggested
explanation
MI.
the
of
10
after
MI.
6
value
QTD
during
days
could
day
might
patient
small number in the
in our
In the MCA
role in the
of
Thrombolytic therapy
play a
group.
which contains
restoration of the
a
group
study,
relatively
electrophysiological stability
cells
small number of
an evi-
The
we observed
myocardial
of
supplying reperfusion.2o°21
patients,
dent
moved
re-
decrease when
of
were
some
(Tr+)
QTD
group
patients receiving
thrombolysis
patients
not
from
In con-
showedlesser
than
throm-
the data.
(because
death)
QTD
patients
given
trast
a
rela-
the
Studies have
indicated
to this
our series involved
and
(Tr-)
bolytics
report,
(p < 0.05).
that
large numberof
demonstrated
com-
patients
tively
data
successfully reperfused
patients
compared
throm-
a
lower incidence of
with
andlate
treated
that
to whether
received
early
mortality
according
they
or
Our
a
ten-
not.
pared
conventionally
patients.10
bolytics
data have
course
demonstrated
shows
Several
assessed the time
QTcD
investigators
the
to
the first
increase
during
10
of
namic
after
interval after
MI,13,14
QT
dy-
dency
indicating
after
days
AMI. This
shows
pattern
patients
group
ventricular
myocar-
increasing
early
recoverychanges
promi-
as
<
in the
MI.
are
nence
in
Tr+
of these effects
that in animal
dial infarction. 14 Mechanisms
not clear. It has been shown
action
0.05)
to Tr-
(p
compared
long-term
group
ex-
after
and
re-
In-hospital
are
shorten
benefits of
durations
thrombolysis
potential
closely
periments,
Toyama
