Bioorganic and Medicinal Chemistry Letters p. 3003 - 3006 (1998)
Update date:2022-09-26
Topics:
Schlienger, Nathalie
Beltran, Thierry
Perigaud, Christian
Lefebvre, Isabelle
Pompon, Alain
Aubertin, Anne-Marie
Gosselin, Gilles
Imbach, Jean-Louis
MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide s
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Doi:10.1002/ardp.19713040608
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