Rational design of a new series of mixed anti-HIV pronucleotides

DOI: 10.1016/S0960-894X(98)00535-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3003 - 3006 (1998)

Update date:2022-09-26

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Authors:

Schlienger, Nathalie

Beltran, Thierry

Perigaud, Christian

Lefebvre, Isabelle

Pompon, Alain

Aubertin, Anne-Marie

Gosselin, Gilles

Imbach, Jean-Louis

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Article abstract of DOI:10.1016/S0960-894X(98)00535-6

MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide s

Full text of DOI:10.1016/S0960-894X(98)00535-6

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