On the reaction of chloroalkylbenzothiazoles with alkaloides

Article abstract of DOI:10.1016/S0040-4020(97)00243-3

2-chloroalkylbenzothiazoles 1a-c react with alkoxides to give substitution and ring-expanded products 3 and 4. The substitution ring-enlargement competition much depends upon the solvent, the substitution reaction being preferred in alcohols and the ring-enlargement in DMF.