Synthesis and reactions of some new 1,2,4-triazine derivatives of biological interest

Article abstract of DOI:10.1080/10426500008046612

4-Amino-3-mercapto-6-methyl-1,2,4-triazin-5(4H)-one (1) and its 5-thioxo derivative 4 were reacted with phenacyl halides at different reaction conditions to yield the S-phenacyl derivatives 2a,b, 5 as well as the corresponding triazino[3,4-b][1,3,4]thiadiazines 3a,b, 6. Treatment of 1 with acrylonitrile gave 4-amino-3-(2-cyanoethyl)thio-6-methyl-1,2,4-triazin-5(4H)-one (7), which was condensed with various aldehydes to afford the corresponding anils 10a-c. Acid hydrolysis of 10b gave the corresponding acid 11, whereas 7 yielded 4-amino-3-hydroxy-6-methyl-5(4H)-oxo-1,2,4-triazine hydrochloride (12) under the same condition. Some new compounds exhibited antibacterial and antifungal activities.

Full text of DOI:10.1080/10426500008046612

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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SYNTHESIS AND REACTIONS
OF SOME NEW 1,2,4-TRIAZINE
DERIVATIVES OF BIOLOGICAL
INTEREST
Nasser R. El-Brollosy a
a Chemistry Department, Faculty of Science , Tanta
University , Tanta, Egypt
Published online: 04 Oct 2006.
To cite this article: Nasser R. El-Brollosy (2000) SYNTHESIS AND REACTIONS OF SOME
NEW 1,2,4-TRIAZINE DERIVATIVES OF BIOLOGICAL INTEREST, Phosphorus, Sulfur, and
Silicon and the Related Elements, 163:1, 77-89, DOI: 10.1080/10426500008046612
To link to this article: http://dx.doi.org/10.1080/10426500008046612
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