Re-examination of the synthesis of 7,8-dimethoxy-2-methyl-3-(4',5'-methylenedioxy-2'-vinylphenyl)isocarbos tyril

DOI: 10.1248/cpb.39.2712

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2712 - 2714 (1991)

Update date:2022-08-04

Topics:

Authors:

Ishii Ishii

Takeda Takeda

Ogata Ogata

Hanaoka Hanaoka

Harayama

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Article abstract of DOI:10.1248/cpb.39.2712

Oxidation of the enamine (6) to the isocarbostyril (7) was re-examined. Simply stirring a dimethylformamide (DMF) solution of 6 provided 7 with good reproducibility, in the presence of KCN under an oxygen atmosphere. The structure of the chloroform adduct (8) was determined by an X-ray analysis.

Full text of DOI:10.1248/cpb.39.2712

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