Green synthesis of α-aminophosphonate derivatives on a solid supported TiO2-SiO2 catalyst and their anticancer activity

Article abstract of DOI:10.1002/ardp.201300214

Syntheses of a new series of biologically potent α-aminophosphonates were accomplished by one-pot Kabachnik-Fields reaction using TiO ₂-SiO₂ as solid supported catalyst under microwave irradiation conditions. The chemical structures of all the newly synthesized compounds were confirmed by analytical and spectral (IR, ¹H, ¹³C, ³¹P NMR, and mass) data. Their anticancer nature was evaluated by screening the in vitro activity on two human cancer cell lines, HeLa and SK-BR-3. Compounds 4i and 4o showed the best activity on these cancer cells even though the majority of the compounds, and particularly 4l and 4p, have good cytotoxic activity against them. TiO₂-SiO₂ was employed as solid supported catalyst for the solvent-free one-pot synthesis of α-aminophosphonates by Kabachnik-Fields reaction under microwave irradiation conditions. The newly synthesized compounds were assessed for in vitro anticancer activity against HeLa and SK-BR-3 cells. The majority of the compounds showed good cytotoxic activity.