Organic Process Research and Development p. 110 - 115 (2001)
Update date:2022-08-03
Topics:
Pflum, Derek A.
Wilkinson, H. Scott
Tanoury, Gerald J.
Kessler, Donald W.
Kraus, Hali B.
Senanayake, Chris H.
Wald, Stephen A.
Enantiomerically pure cetirizine can be prepared by preparative HPLC separation of cetirizine amide. The amide has an α value of 2.76 (USP resolution of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run.
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(2000)
