Chiral nonracemic C2-symmetry biphenyls by desymmetrization of 6,6',2,2'-tetramethoxy-1,1'-biphenyl

Article abstract of DOI:10.1016/S0957-4166(00)00410-9

Regioselective bromination of the title biphenyl 1 at the 3 and 3' positions and simultaneous desymmetrization of the biphenyl has been achieved. Metal-halide exchange at the 3,3' positions facilitated the introduction of functional groups in good yield.