The stereochemistry of organometallic compounds XXXVI. Rhodium-catalysed reactions of unsaturated amines with hydrogen and carbon monoxide. A new synthesis of 2-piperidinones

Article abstract of DOI:10.1016/0022-328X(91)80065-R

Rhodium-catalysed reactions of 5-aminopent-1-enes with carbon monoxide and hydrogen give 2-piperidinone derivatives in high yields under mild conditions.Reaction of allylamine under similar conditions gave exclusively 2-pyrrolidone in high yield and reactions of 4-aminobut-1-enes gave mixtures of 2-piperidinones and 2-pyrrolidinones.The role of the hydrogen in these reactions is discussed.