Facile synthesis of (R)-4-mercaptopyrrolidine-2-thione from l-aspartic acid

Article abstract of DOI:10.1271/bbb.65.973

An SN2-type of substitution of (S)-bromide 4, which had been prepared from L-aspartic acid, with potassium thiobenzoate provided (R)-benzoylthio derivative 5 with complete inversion of the configuration. Compound 5 was converted, via iodide 6c, to (R)-4-a

Full text of DOI:10.1271/bbb.65.973

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Facile Synthesis of (R)-4-Mercaptopyrrolidine-2-
thione from L-Aspartic Acid
Masahiko SEKIa & Toshiaki SHIMIZUa
a Product & Technology Development Laboratory, Tanabe Seiyaku Co. Ltd.
Published online: 22 May 2014.
To cite this article: Masahiko SEKI & Toshiaki SHIMIZU (2001) Facile Synthesis of (R)-4-Mercaptopyrrolidine-2-thione from
L-Aspartic Acid, Bioscience, Biotechnology, and Biochemistry, 65:4, 973-976, DOI: 10.1271/bbb.65.973
To link to this article: http://dx.doi.org/10.1271/bbb.65.973
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