Journal of the Chemical Society. Perkin transactions I p. 5 - 12 (1972)
Update date:2022-09-26
Topics: Synthesis Chromatography Peptide Synthesis Amino Acid Derivatives Peptide Bond Formation Polypeptides Sequential polypeptides
Hardy
Rydon
Thompson
The succinimidyl esters of mono-, di-, tri-, and tetra-γ-benzyl-D- glutamyl-L-leucine (VII; n = 1-4) have been prepared from the corresponding acids (V; n = 1-4), which were synthesised by the dicyclohexylcarbodi-imide method; the t-butoxycarbonyl group was used for amino-group protection and the 2-methylthioethyl ester group for carboxy-protection. Polymerisation of these esters gave satisfactory yields of the corresponding sequential polypeptides (I; n = 1-4) with molecular weights of between 11,000 and 31,000. Little racemisation (1-2%) accompanies the polymerisations, and the method is recommended as a procedure of choice for the synthesis of sequential polypeptides.
View MoreJiangsu Zhenfang Chemical CO.,LTD.(Suzhou Zhenfang Chemical Factory)
Contact:+86-512-69598882
Address:Room1201, Jiayuan Road No.1018, Xiangcheng District, Suzhou, China
Contact:+86-531-58668191 58668193 58668196 58661173
Address:No 55,Beixiaoxinzhuang West Street,Jinan City, Shandong Province
Shanghai Yuanye Bio-Technology Co., Ltd.
website:http://www.shyuanye.com
Contact:+86-21-61845781
Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China
Airsea(Taizhou) Pharmaceutical Limited(expird)
Contact:+86-576-88057622
Address:Dubei, Duqiao, Linhai, Taizhou, Zhejiang, China Zip: 317016
Jining tiansheng chemical co.,ltd.
Contact:+86-537-5158722
Address:ROOM 1011, BLOCK B, CUIDU INTERNATIOAL BUSINESS CENTER, JINING CITY, CHINA
Doi:10.1016/j.dyepig.2019.107965
(2020)Doi:10.1055/s-1998-1885
(1998)Doi:10.1016/S0014-827X(01)01081-3
(2001)Doi:10.1007/BF01158506
()Doi:10.1002/anie.201702940
(2017)Doi:10.1016/S0040-4039(01)01020-6
(2001)
