Synthesis of spiro[isoquinoline-4,4′-pyran]-3-imines

Article abstract of DOI:10.1007/BF02256974

A method has been developed for the synthesis of 4-[2-(bromomethyl)phenyl]tetrahydro-2H-4-pyrancarbonitrile and a study was carried out on the reaction of this compound with primary amines, which, depending on the conditions, leads to either 4-[2-(R-aminomethyl)phenyl]tetrahydro-2H-4-pyrancarbonitriles or hydrobromides of 2-R- aryl-2,3,2′,3′,5′,6′-hexahydrospiro[isoquinoline- 4(1H),4′-pyran]-3-imines.