Aspartic protease inhibitors: Expedient synthesis of 2-substituted statines

DOI: 10.1021/ol016331d

Source and publish data:

Organic Letters p. 2725 - 2728 (2001)

Update date:2022-07-30

Topics:

Authors:

Travins, Jeremy M.

Bursavich, Matthew G.

Veber, Daniel F.

Rich, Daniel H.

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Article abstract of DOI:10.1021/ol016331d

(Equation presented) General stereocontrolled synthesis of all four (2,3)-stereoisomers of 2-substituted statines is described. The 2,3-syn and 2,3-anti isomers were synthesized via β-ketoester reduction and aldol reactions, respectively. Peptides contain

Full text of DOI:10.1021/ol016331d

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