Cyclocondensation of ethylenediamine with acetone and methyl ethyl ketone as a synthetic route to 14-membered azamacrocyclic compounds

Article abstract of DOI:10.1134/S1070363215090108

14-Membered azamacrocyclic compounds, substituted 1,4,8,11-tetraazacyclotetradeca-4,11-diene and 1,4,8,11-tetraazacyclotetradeca-4,14-diene containing azomethine cycle and amine nitrogen atoms, were obtained as a mixture of trans- and cis-isomers by reacting ethylenediamine with acetone and methyl ethyl ketone. More stable trans-isomers were isolated individually by vacuum distillation.