Phosphorus, Sulfur and Silicon and the Related Elements p. 2245 - 2252 (2004)
Update date:2022-07-30
Topics:
Deeb, Ali
Kotb, Mahmoud
El-Abbasy, Mohamed
3-Substituted pyrimido[4′,5′:4,5]thieno[2,3-c/pyridazine-2,4- di-ones and 3-amino-2-methylpyrimido[4′,5′:4,5]thieno[2,3-c] pyridazine-4-ones were synthesized starting from ethyl 5-aminothieno[2,3-c] pyridazine-6-carboxylate 1. Reaction of amino ester 1 with phenyl isothiocyanate affords thiourea derivative 10 which undergo further transformation to the related fused heterocyclic systems.
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