European Journal of Medicinal Chemistry p. 93 - 103 (2018)
Update date:2022-08-03
Topics:
Plebanek, Elzbieta
Lescrinier, Eveline
Andrei, Graciela
Snoeck, Robert
Herdewijn, Piet
De Jonghe, Steven
The synthesis of emimycin, 5-substituted emimycin analogues and the corresponding ribo- and 2′-deoxyribonucleoside derivatives is described. Emimycin, its 5-substituted congeners and the ribonucleoside derivatives are completely devoid of antiviral activity against RNA viruses. In contrast, some of the 2′-deoxyribosyl emimycin derivatives are potent inhibitors of the replication of herpes simplex virus-1 and varicella-zoster virus, lacking cytotoxicity.
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