Cycloaddition of homophthalic anhydrides with aldehydes and ketones: A route to 3,4-dihydroisocoumarin-4-carboxylic acid derivatives

Article abstract of DOI:10.1016/S0040-4020(99)00840-6

Homophthalic anhydride reacts with benzaldehyde, in the presence of boron trifluoride - diethyl ether complex to give the cycloadduct 3-phenyl- 3,4-dihydroisocoumarin-4-carboxylic acid in good to excellent yield. Under these conditions, we did not observe