Substrate properties of adenosine- and uridine- 3', 5'- bisphenylphosphonates for 3'-nucleotidase/nucleases

Article abstract of DOI:10.1080/07328319608002456

3', 5'-Bisphenylphosphonate and 5'-phenylphosphonate esters of adenosine and uridine were synthesized to investigate the substrate properties of the 3', 5'-bisphenylphosphonates for 3'-nucleotidase/nucleases. The V(max)/apparent K(m) values of the enzymes for them were found to be 9 to 21- fold higher than those for the corresponding nucleoside 3'- phenylphosphonates.

Full text of DOI:10.1080/07328319608002456

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Nucleosides and Nucleotides
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Substrate Properties of Adenosine- and
Uridine- 3′, 5′-bisphenylphosphonates
for 3′-Nucleotidase/Nucleases
H. Uchida a , T. Oohara a , H. Wada a , I. Takahashi a & A. Nomura a
a Department of Applied Chemistry and Biotechnology , Faculty of
Engineering, Fukui University , Bunkyo 3-9-1, Fukui, 910, Japan
Published online: 20 Aug 2006.
To cite this article: H. Uchida , T. Oohara , H. Wada , I. Takahashi & A. Nomura (1996) Substrate
Properties of Adenosine- and Uridine- 3′, 5′-bisphenylphosphonates for 3′-Nucleotidase/Nucleases,
Nucleosides and Nucleotides, 15:10, 1561-1566, DOI: 10.1080/07328319608002456
To link to this article: http://dx.doi.org/10.1080/07328319608002456
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