Synthesis of substituted-benzyl and sugar-modified analogues of 6-N-(4- nitrobenzyl)adenosine and their interactions with 'ES' nucleoside transport systems

Article abstract of DOI:10.1080/15257779408012177

Four classes of 6-X-benzylated purine nucleosides, (i) 6-N-(substituted- benzyl)adenosines, (ii) 6-N-(4-nitrobenzyl)adenine nucleosides with modified sugars, (iii) 6-N(S)-(4-azidobenzyl) derivatives of adenosine, 6-thioinosine, and 6-thioguanosine, and (iv) 6-N-{4-N-[acyl(sulfonyl)amino]benzyl} adenosines, were synthesized and their binding interactions with 'es-NT' (equilibrative, inhibitor-sensitive nucleoside transport) systems were studied. Several tight-binding analogues were found.

Full text of DOI:10.1080/15257779408012177

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Synthesis of Substituted-Benzyl and
Sugar-Modified Analogues of 6-N-
(4-Nitrobenzyl)adenosine and Their
Interactions with “ES” Nucleoside
Transport Systems
Morris J. Robins a e , Jun-ichi Asakura a e , Masakatsu Kaneko a
,
Susumu Shibuya a , Ewa S. Jakobs d , Francisca R. Agbanyo d , Carol
E. Cass b d & Alan R. P. Paterson c d
a Department of Chemistry , University of Alberta , Edmonton,
Alberta, Canada , T6G 2H7
b Department of Biochemistry , University of Alberta , Edmonton,
Alberta, Canada , T6G 2H7
c Department of Pharmacology , University of Alberta , Edmonton,
Alberta, Canada , T6G 2H7
d Department of McEachern Laboratory , University of Alberta ,
Edmonton, Alberta, Canada , T6G 2H7
e Department of Chemistry , Brigham Young University , Provo, UT,
84602, U.S.A.
Published online: 24 Sep 2006.
To cite this article: Morris J. Robins , Jun-ichi Asakura , Masakatsu Kaneko , Susumu Shibuya , Ewa S.
Jakobs , Francisca R. Agbanyo , Carol E. Cass & Alan R. P. Paterson (1994) Synthesis of Substituted-
Benzyl and Sugar-Modified Analogues of 6-N-(4-Nitrobenzyl)adenosine and Their Interactions
with “ES” Nucleoside Transport Systems, Nucleosides and Nucleotides, 13:6-7, 1627-1646, DOI:
10.1080/15257779408012177
To link to this article: http://dx.doi.org/10.1080/15257779408012177
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