Structure-activity studies on antidepressant 2,2-diarylethylamines

DOI: 10.1021/jm00374a022

Source and publish data:

Journal of Medicinal Chemistry p. 1067 - 1071 (1984)

Update date:2022-08-03

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Authors:

Maryanoff

Nortey Nortey

Gardocki

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Article abstract of DOI:10.1021/jm00374a022

A series of 2,2-diarylethylamine derivatives has been examined for potential antidepressant activity in the tetrabenazine(TBZ) test. Diethanolamine 4 (McN-4187) was one of the more potent compounds despite its polar alcohol functionalities [ED_{50
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Full text of DOI:10.1021/jm00374a022

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