N-Heterocyclic Carbene Catalyzed Deuteration of Aldehydes in D 2 O

DOI: 10.1055/s-0040-1707993

Source and publish data:

Synlett p. 699 - 702 (2020)

Update date:2022-08-05

Topics:

Authors:

Miki, Yuya

Sajiki, Hironao

Sawama, Yoshinari

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Article abstract of DOI:10.1055/s-0040-1707993

An N-heterocyclic carbene (NHC)-catalyzed direct deuteration of aldehydes in a mixed solvent of deuterium oxide (D ₂ O) and cyclopentyl methyl ether was established. The present deuteration is possibly initiated by the formation of a Breslow intermediate from the aldehyde and the NHC, with subsequent trapping by D ₂ O providing the monodeuterated aldehyde.

Full text of DOI:10.1055/s-0040-1707993

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