Chimia p. 634 - 639 (2004)
Update date:2022-08-05
Topics:
Boss, Christoph
Richard-Bildstein, Sylvia
Furnari, Rocco
Bourgeois, Jean-Marc
Corminboeuf, Olivier
Grisostomi, Corinna
Coppex, Lionel
Harris, Luke
Prade, Lars
Meyer, Solange
Binkert, Christoph
Fischli, Walter
Brun, Reto
Weller, Thomas
Malaria is a very serious infectious disease affecting over two billion people worldwide. Currently available antimalarial drugs are losing effectiveness due to the emergence and the spread of resistant parasite strains. In order to regain control over the disease, new treatments are urgently needed. Drug discovery efforts in this direction are most likely to be successful if they target a novel mechanism of action. Such approaches will lead to antimalarial medicines that are functionally and structurally different from the existing drugs and therefore will have the potential to overcome existing resistances. Our own efforts are focused on the aspartic protease plasmepsin II (PMII) which is a promising new drug target for future antimalarial therapies. We have found structurally simple, moderately active, non-peptide inhibitors of plasmepsin II which offer ample opportunity for further optimization efforts.
View MoreFujian Huitian Biological Pharmacy Co., Ltd.
Contact:0086-598-8300831; 8339920
Address:No.46,Taijiang Road,Sanming City,Fujian,China
WUXI HONOR SHINE CHEMICAL CO.,LTD
Contact:+86-510-83593312
Address:No.1699 Huishan avenue,Huishan district,Wuxi ,Jiangsu,China,214177.(Wuxi Huishan Ecomonic Develop Zone )
website:http://www.mascot-ie.com
Contact:86-519-85010339
Address:B-802,XingBei Building,391#,Tongjiang Middle Road New District,Changzhou,JS,China
Hangzhou Mole's Science & Technology Co.,Ltd.(expird)
Contact:+86-571-56880228
Address:15F Guodu development Building, NO.182 Zhaohui Road
shijiazhuang shuanglian chemical industry co.,ltd
Contact:0311-82190302
Address:Luquan Intersection , Shijiazhuang--Taiyuan Expressway,Shijiazhuang City
Doi:10.1016/S0040-4020(01)88339-3
(1992)Doi:10.1016/S0040-4039(01)87939-9
(1969)Doi:10.1016/S0022-328X(00)93826-9
(1980)Doi:10.1021/ja00800a059
(1973)Doi:10.1021/jo00916a009
(1974)Doi:10.1002/jhet.5570100319
(1973)