Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan p. 554 - 565 (1973)
Update date:2022-08-03
Topics:
Igarashi
Kurihara
In order to investigate the relation between chemical structure and pharmacological properties, 68 new compounds belonging to amino alcohol derivatives were synthesized. One of them showed twice as potent an analgesic activity as barbipyrine, and five of them were found to be as effective as barbipyrine. Antispasmodic activity was recognized in the solution of these compounds at the concentration from 10-4 to 10-7 g/ml. Almost all the compounds were shown to have local anesthetic activity and the duration of the activity of several substances was more than 120 min. In general, the pharmacological activity decreased in the order of aminoolefins, urethans, amino alcohols, and alkamine esters.
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Doi:10.1139/v73-414
(1973)Doi:10.1016/S0968-0896(01)00309-1
(2002)Doi:10.1021/ja01131a058
(1952)Doi:10.1016/j.ejmech.2013.10.069
(2014)Doi:10.1002/hlca.19730560424
(1973)Doi:10.1016/S0022-328X(01)01284-0
(2002)
