Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan p. 554 - 565 (1973)
Update date:2022-08-03
Topics:
Igarashi
Kurihara
In order to investigate the relation between chemical structure and pharmacological properties, 68 new compounds belonging to amino alcohol derivatives were synthesized. One of them showed twice as potent an analgesic activity as barbipyrine, and five of them were found to be as effective as barbipyrine. Antispasmodic activity was recognized in the solution of these compounds at the concentration from 10-4 to 10-7 g/ml. Almost all the compounds were shown to have local anesthetic activity and the duration of the activity of several substances was more than 120 min. In general, the pharmacological activity decreased in the order of aminoolefins, urethans, amino alcohols, and alkamine esters.
View MoreContact:+86-021-58123769
Address:No.780 of Cailun Road,Zhangjiang Hi-tech Park,Pudong,Shanghai
Chengdu Sino-Strong Pharmaceutical Co.,Ltd.
website:http://www.sino-strong.com.cn
Contact:+86-28-82666753
Address:459 West haike road,Cross-straits technological industry park, Wenjiang district,Chengdu, P.R.China
Contact:+86-27-87204219, +86-27-87215023
Address:2402, HuiGu Space-time Building, 8 Forest Road, East Lake Hi-Tech Development Zone
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Contact:+86-21-5161 3915
Address:Shanghai YangPu
Nanjing Xi Ze Biological Technology Co., Ltd
Contact:86-025-66023220
Address:Address: Nanjin Qixia District Maigaoqiao R & D base in Pioneer Park Chun Yin Road 18-A928
Doi:10.1139/v73-414
(1973)Doi:10.1016/S0968-0896(01)00309-1
(2002)Doi:10.1021/ja01131a058
(1952)Doi:10.1016/j.ejmech.2013.10.069
(2014)Doi:10.1002/hlca.19730560424
(1973)Doi:10.1016/S0022-328X(01)01284-0
(2002)
