Solution-phase parallel synthesis of a pharmacophore library of HUN-7293 analogues: A general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides

DOI: 10.1021/ja020166v

Source and publish data:

Journal of the American Chemical Society p. 5431 - 5440 (2002)

Update date:2022-07-30

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Authors:

Chen, Yan

Bilban, Melitta

Foster, Carolyn A.

Boger, Dale L.

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Article abstract of DOI:10.1021/ja020166v

HUN-7293 (1), a naturally occurring cyclic heptadepsipeptide, is a potent inhibitor of cell adhesion molecule expression (VCAM-1, ICAM-1, E-selectin), the overexpression of which is characteristic of chronic inflammatory diseases. Representative of a gene

Full text of DOI:10.1021/ja020166v

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