Bioorganic and medicinal chemistry letters p. 861 - 864 (2002)
Update date:2022-07-29
Topics:
Isomura, Shigeki
Ashley, Jon A
Wirsching, Peter
Janda, Kim D
Vancomycin resistance is currently a major healthcare problem. The development of a catalytic monoclonal antibody (mAb) that hydrolyzes the D-Ala-D-Lac depsipeptide provides a potentially novel antibiotic strategy. A phosphonate hapten design was used to program antibody catalysis. The characteristics of the hapten were shown to be important for obtaining a viable immune response and several catalytic mAbs that cleave a peptidoglycan model substrate. The best mAb afforded a >500-fold rate enhancement over background.
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Doi:10.1007/BF01169914
()Doi:10.1021/ja01860a048
(1940)Doi:10.1021/ol026633v
(2002)Doi:10.1023/A:1015888706390
(2002)Doi:10.1021/om020444z
(2002)Doi:10.1021/om020400q
(2002)