Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies

DOI: 10.1016/j.bmcl.2005.07.023

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4417 - 4420 (2005)

Update date:2022-08-03

Topics:

Authors:

Shankar, Bandarpalle B.

Lavey, Brian J.

Zhou, Guowei

Spitler, James A.

Tong, Ling

Rizvi, Razia

Yang, De-Yi

Wolin, Ronald

Kozlowski, Joseph A.

Shih, Neng-Yang

Wu, Jie Wu, Jie

Hipkin, R. William

Gonsiorek, Waldemar

Lunn, Charles A.

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Article abstract of DOI:10.1016/j.bmcl.2005.07.023

We recently reported that compound 1 is a potent inhibitor of the CB2 receptor with high selectivity over CB1. This paper describes the SAR development for this class of compounds. Variation of the substitution pattern on the aromatic rings, as well as th

Full text of DOI:10.1016/j.bmcl.2005.07.023

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