Tetrahedron Letters p. 2235 - 2238 (1998)
Update date:2022-08-04
Topics:
Fokas, Demosthenes
Ryan, William J.
Casebier, David S.
Coffen, David L.
A combinatorial library of 26,500 spiro[pyrrolidine,-2,3-oxindoles] was prepared in a single-compound format by a facile intermolecular 1,3-dipolar cycloaddition. An azomethine ylide, generated by the decarboxylative condensation of an isatin 1 with an α-amino acid 2, was trapped by a transchalcone 3 to afford heterocycles of the general structure 4. The regio- and stereochemistry of a representative product was determined by single crystal X-ray structure.
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