Design and Synthesis of Tetrahedral Intermediate Analogues as Potential Dihydroorotase Inhibitors

DOI: 10.1021/jm00368a022

Source and publish data:

Journal of Medicinal Chemistry p. 228 - 232 (1984)

Update date:2022-08-02

Topics:

Authors:

Levenson, Corey H.

Meyer, Rich B.

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Article abstract of DOI:10.1021/jm00368a022

Three new heterocyclic analogues (4-6) of dihydroorotic acid were designed, synthesized, and tested as inhibitors of dihydroorotase.Each compound possessed a tetrahedral sulfur atom at the position equivalent to carbon 4 in the dihydroorotate ring in an a

Full text of DOI:10.1021/jm00368a022

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