Design and Synthesis of Tetrahedral Intermediate Analogues as Potential Dihydroorotase Inhibitors

DOI: 10.1021/jm00368a022

Source and publish data:

Journal of Medicinal Chemistry p. 228 - 232 (1984)

Update date:2022-08-02

Topics:

Authors:

Levenson, Corey H.

Meyer, Rich B.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00368a022

Three new heterocyclic analogues (4-6) of dihydroorotic acid were designed, synthesized, and tested as inhibitors of dihydroorotase.Each compound possessed a tetrahedral sulfur atom at the position equivalent to carbon 4 in the dihydroorotate ring in an a

Full text of DOI:10.1021/jm00368a022

Products guided by the article

Product name:methyl N-(benzyloxycarbonyl)-S-methylcysteinate sulfoxide

Cas No:452898-02-1

R&D Labs maybe for 452898-02-1

Xinjiang Zhongtai Chemical Co., Ltd.

Contact:+86-991-8788172

Address:NO.78 XISHAN RD.URUMQI，CHINA
Shanghai Pengkai Chemical Co.,Ltd

Contact:+86-21-60526671

Address:No.4226 Duzhuang Rd Minhang District Shanghai China
Chengdu Gelipu Biotechnology Co., Ltd.

website:http://www.glp-china.com

Contact:86-28-82610909

Address:chegndu
Shanghai Profirst Co., Ltd.

Contact:+86-21-38122007

Address:2, Lane 1123, Kangqiao Road, Pudong New Area, Shanghai
HOST COUNTRY LIMITED

Contact:+852 83038667

Address:Room 1502, 15th Floor, SPA Centre,53-55 Lockhart Road, Wanchai, Hong Kong

Relevant to this article

An efficient, one-pot three components synthesis of [1,2,4] triazoloquinazolinone derivatives using anthranilic acid as green catalyst

Doi:10.1007/s11164-017-2896-5
(2017)
Doi:10.1021/ja01202a071
(1947)
Synthesis of a molecular mimic of the Glc₁Man₉ oligoside as potential inhibitor of calnexin binding to ΔF508 CFTR protein

Doi:10.1016/S0960-894X(02)00151-8
(2002)
Aspartame analogues containing 1-amino-2-phenylcyclohexanecarboxylic acids (c₆Phe)

Doi:10.1016/S0040-4020(02)00435-0
(2002)
Base-promoted addition of DMA with 1,1-diarylethylenes: Application to a total synthesis of (-)-sacidumlignan B

Doi:10.1039/d0ob00376j
(2020)
On the verge of axial chirality: Atroposelective synthesis of the AB-biaryl fragment of vancomycin

Doi:10.1021/ol026182e
(2002)

Article Doi