Design and Synthesis of Tetrahedral Intermediate Analogues as Potential Dihydroorotase Inhibitors

Article abstract of DOI:10.1021/jm00368a022

Three new heterocyclic analogues (4-6) of dihydroorotic acid were designed, synthesized, and tested as inhibitors of dihydroorotase.Each compound possessed a tetrahedral sulfur atom at the position equivalent to carbon 4 in the dihydroorotate ring in an a