Journal of Medicinal Chemistry p. 573 - 577 (1975)
Update date:2022-08-05
Topics:
Greenwood
Mallion
Todd
Turner
Some 2 aryloxymethyl 2,3,5,6 tetrahydro 1,4 oxazines have been shown to possess marked antidepressant activity. The 1,4 oxazines were synthesized by lithium aluminium hydride reduction of the readily available 6 aryloxymethyl 2,3,5,6 tetrahydro 1,4 oxazin 3 ones. High antidepressant activity was associated with ortho substitution of the 2 phenoxymethyl group and with 1,4 oxazines devoid of 4 substituents.
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Doi:10.1016/j.bmcl.2003.12.063
(2004)Doi:10.1021/jm00258a006
(1974)Doi:10.1139/v74-428
(1974)Doi:10.1002/prac.19743160322
(1974)Doi:10.1021/ja00824a068
(1974)Doi:10.1246/bcsj.47.2627
(1974)
